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Key points: We need to eat in a calorie deficit to lose weight If our baseline diet is rich in ultra-processed foods and we continue to eat this way on semaglutide, we may still consume more calories than we need to lose weight It’s essential to eat a diet based on whole foods to support sustainable weight loss 2) You’re in a weight-loss plateau Suppose we’ve lost some weight on semaglutide, but then we hit a plateau, and we can’t budge the scales any more
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Sigma-Aldrich) was used, while 0.5 μM of the endoplasmic reticulum stress inducer thapsigargin (Sigma-Aldrich) was applied to activate SREBP-2, thereby upregulating genes involved in cholesterol biosynthesis and uptake [22]
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