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Discussion This is the first systematic review and meta-analysis focused exclusively on RCTs evaluating major cardiovascular events (MACE)
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Pro-inflammatory cytokines increase neuronal vulnerability to apoptosis and oxidative stress by activating enzymes such as JNK, ERK, dsRNA-dependent protein kinase (PKR), and IB kinase (IKK) that reduce insulin sensitivity by serine phosphorylation of IRS1 [144, 145]
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