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The aromatase encoded by the CYP19A1 gene is a key rate limiting enzyme in the estradiol (E2) synthesis pathway.11 When abnormal expression of CYP19A1 or inhibition of aromatase activity occurs, the conversion of androgens to E2 is restricted.12,13 Chronic low-grade inflammation is considered a vital triggering factor for the development of PCOS.14,15 Patients with PCOS exhibit pathological changes in the ovaries, mainly bilateral ovarian enlargement, thickening and sclerosis of the white membrane, cortical fibrosis, and significant interstitial hyperplasia of the ovaries
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Compounded formulations from licensed 503A pharmacies also require proper handling and storage verification to ensure medication integrity
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