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Research has also described a distinct potency pattern across its receptor targets: Strong GIP receptor activity (around 8.9× higher than native GIP) Moderate GLP-1 receptor activation (about 0.4× relative potency) Modest glucagon receptor activity (about 0.3× relative potency) This balanced profile provides a framework for studying coordinated metabolic responses rather than isolated single-pathway effects
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Daniel Drucker [Biomarker April 2023] Can GLP-1/GIP therapies improve long term health outcomes
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