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The medications work through three overlapping mechanisms: they reduce appetite by acting on hunger centers in the brainstem and hypothalamus, they slow gastric emptying so food stays in the stomach longer (increasing fullness), and they improve insulin sensitivity (which stabilizes blood sugar and reduces cravings driven by glucose swings)
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Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
